Prodrug

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Ribonuclease-Activated Cancer Prodrug.

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Prodrug Strategies for Paclitaxel

Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from al...

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Cytomegalovirus Protease Targeted Prodrug Development

Human cytomegalovirus (HCMV) is a prevalent virus that infects up to 90% of the population. The goal of this research is to determine if small molecular prodrug substrates can be developed for a specific HCMV encoded protease and thus achieve site-specific activation. HCMV encodes a 256 amino acid serine protease that is responsible for capsid assembly, an essential process for herpes virus pro...

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Prodrug Design vs. Drug Design

A drug is defined as a substance which is used in the cure, relief, diagnosis, treatment, or prevention of disease. The development of any potential drug commences with the study of the biochemistry and physiology behind a disease for which pharmaceutical intervention is feasible [1]. Prodrug is a term that was first introduced by Albert to signify a pharmacologically inactive chemical moiety t...

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Substrate Mediated Enzyme Prodrug Therapy

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ژورنال

عنوان ژورنال: Ensho

سال: 1981

ISSN: 0389-4290,1884-4006

DOI: 10.2492/jsir1981.1.2_316